Publications

2023

Angerer N, Piller P, Semeraro EF, Keller S, Pabst G. Interaction of detergent with complex mimics of bacterial membranes. Biophys. Chem. 2023. PMID 36921495

Eggenreich L, Vargas C, Kolar C, Keller S. Lipid exchange among electroneutral Sulfo-DIBMA nanodiscs is independent of ion concentration. Biol. Chem. 2023. PMID 36921292

Lenz J, Larsen AH, Keller S, Luchini A. Effect of cholesterol on the structure and composition of Glyco-DIBMA lipid particles. Langmuir 2023, 39, 3569. PMID 36854196

Baron J, Bauernhofer L, Devenish SRA, Fiedler S, Ilsley A, Riedl S, Zweytick D, Glueck D, Pessentheiner A, Durand G, Keller S. FULL-MDS: fluorescent universal lipid labeling for microfluidic diffusional sizing. Anal. Chem. 2023, 95, 587. PMID 36574263

Soulié M, Deletraz A, Wehbie M, Mahler F, Bouchemal I, Le Roy A, Petit-Härtlein I, Keller S, Meister A, Pebay-Peyroula E, Breyton C, Ebel C, Durand G. Zwitterionic fluorinated detergents: from design to membrane protein applications. Biochimie 2023, 205, 40. PMID 36375632

Jeblick T, Leisen T, Steidele CE, Albert I, Müller J, Kaiser S, Mahler F, Sommer F, Keller S, Hückelhoven R, Hahn M, Scheuring D. Botrytis hypersensitive response inducing protein 1 triggers noncanonical PTI to induce plant cell death. Plant Physiol. 2023, 191, 125. PMID 36222581

2022

Janson K, Kyrilis FL, Tüting C, Alfes M, Das M, Träger TK, Schmidt C, Hamdi F, Vargas C, Keller S, Meister A, Kastritis PL. Cryo-electron microscopy snapshots of eukaryotic membrane proteins in native lipid-bilayer nanodiscs. Biomacromolecules 2022, 23, 5084. PMID 36399657

Lee HS, Das M, Mahler F, Ahmed W, Wang H, Mortensen JS, Hariharan P, Ghani L, Byrne B, Guan L, Loland CJ, Keller S, Chae PS. 3,4-Bis(hydroxymethyl)hexane-1,6-diol-based maltosides (HDMs) for membrane-protein study: importance of detergent rigidity–flexibility balance in protein stability. Chem. Asian J. 2022, 17, e202200941. PMID 36253323

Glueck D, Grethen A, Das M, Mmeka OP, Pérez Patallo E, Meister A, Rajender R, Kins S, Räschle M, Victor J, Chu C, Etzkorn M, Köck Z, Bernhard F, Babalola JO, Vargas C, Keller S. Electroneutral polymer nanodiscs enable interference-free probing of membrane proteins in a lipid-bilayer environment. Small 2022, 18, 2202492. PMID 36228092

Piller P, Wolinski H, Cordfunke RA, Drijfhout JW, Keller S, Lohner K, Malanovic N. Membrane activity of LL-37 derived antimicrobial peptides against Enterococcus hirae: superiority of SAAP-148 over OP-145. Biomolecules 2022, 12, 523. PMID 35454112

Danielczak B, Rasche M, Lenz J, Pérez Patallo E, Weyrauch S, Mahler F, Agbadaola MT, Meister A, Babalola JO, Vargas C, Kolar C, Keller S. A bioinspired glycopolymer for capturing membrane proteins in native-like lipid-bilayer nanodiscs. Nanoscale 2022, 5, 1855. PMID 35040850

2021

Schumann R, Bischoff E, Klaus S, Möhring S, Flock J, Keller S, Remans K, Ganter M, Deponte M. Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum. Redox Biol. 2021, 48, 102177. PMID 34773836

Mahler F, Meister A, Vargas C, Durand G, Keller S. Self-assembly of protein-containing lipid-bilayer nanodiscs from small-molecule amphiphiles. Small 2021, 17, 2103603. PMID 34674382

Grousson E, Mahler F, Keller S, Contino-Pépin C, Durand G. Hybrid fluorocarbon–hydrocarbon surfactants: synthesis and colloidal characterization. J. Org. Chem. 2021, 86, 14672. PMID 34609857

Tomazic N, Overkamp KE, Wegner H, Gu B, Mahler F, Aras M, Keller S, Pierik AJ, Hofmann E, Frankenberg-Dinkel N. Exchange of a single amino acid residue in the cryptophyte phycobiliprotein lyase GtCPES expands its substrate specificity. Biochim. Biophys. Acta Bioenerg. 2021, 1862, 148493. PMID 34537203

Janson K, Zierath J, Kyrilis FL, Semchonok DA, Hamdi F, Skalidis I, Kopf AH, Das M, Kolar C, Rasche M, Vargas C, Keller S, Kastritis PL, Meister A. Solubilization of artificial mitochondrial membranes by amphiphilic copolymers of different charge. Biochim. Biophys. Acta Biomembr. 2021, 1863, 183725. PMID 34384757

Hoffmann M, Haselberger D, Hofmann T, Müller L, Janson K, Meister A, Das M, Vargas C, Keller S, Kastritis PL, Schmidt C, Hinderberger D. Nanoscale model system for the human myelin sheath. Biomacromolecules 2021, 22, 3901. PMID 34324309

Hoffmann M, Eisermann J, Schöffmann FA, Das M, Vargas C, Keller S, Hinderberger D. Influence of different polymer belts on lipid properties in nanodiscs characterized by CW EPR spectroscopy. Biochim. Biophys. Acta Biomembr. 2021, 1863, 183681. PMID 34186033

Velazquez-Campoy A, Claro B, Abian O, Höring J, Bourlon L, Claveria-Gimeno R, Ennifar E, England P, Chaires JB, Wu D, Piszczek G, Brautigam C, Tso SC, Zhao H, Schuck P, Keller S, Bastos M. A multi-laboratory benchmark study of isothermal titration calorimetry (ITC) using Ca²⁺ and Mg²⁺ binding to EDTA. Eur. Biophys. J. 2021, 50, 4291. PMID 33864101

Wehbie M, Onyia KK, Mahler F, Le Roy A, Deletraz A, Bouchemal I, Vargas C, Babalola JO, Breyton C, Ebel C, Keller S, Durand G. Maltose-based fluorinated surfactants for membrane-protein extraction and stabilization. Langmuir 2021, 37, 2111. PMID 33539092

Eisermann J, Hoffmann M, Schöffmann FA, Das M, Vargas C, Keller S, Hinderberger D. Molecular-level interactions of nanodisc-forming copolymers dissected by EPR spectroscopy. Macromol. Chem. Phys. 2021, 222, 2100051.

2020

Das M, Mahler F, Hariharan P, Wang H, Du Y, Mortensen JS, Patallo EP, Ghani L, Glück D, Lee HJ, Byrne B, Loland CJ, Guan L, Kobilka BK, Keller S, Chae PS. Diastereomeric cyclopentane-based maltosides (CPMs) as tools for membrane protein study. J. Am. Chem. Soc. 2020, 142, 21382. PMID 33315387

Danielczak B, Keller S. Lipid exchange among polymer-encapsulated nanodiscs by time-resolved Förster resonance energy transfer. Methods 2020, 180, 27. PMID 32371238

Adão R, Cruz PF, Vaz DC, Fonseca F, Pedersen JN, Ferreira-da-Silva F, Brito RMM, Ramos CHI, Otzen D, Keller S, Bastos M. DIBMA nanodiscs keep α-synuclein folded. Biochim. Biophys. Acta Biomembr. 2020, 1862, 183314. PMID 32304757

Tso SC, Mahler F, Höring J, Keller S, Brautigam CA. Fast and robust quantification of detergent micellization thermodynamics from isothermal titration calorimetry. Anal. Chem. 2020, 92, 1154. PMID 31829010

Bonnet C, Guillet P, Mahler F, Igonet S, Keller S, Jawhari A, Durand G. Detergent-like polymerizable monomers: synthesis, physicochemical, and biochemical characterization. Eur. J. Org. Chem. 2020, 33, 5340.

Nickolaus C, Vargas C, Reichenwallner J, Chakour M, Selmke B, Chakraborty R, Varadarajan R, Keller S, Trommer WE. The molten globule state of maltose-binding protein: structural and thermodynamic characterization by EPR spectroscopy and isothermal titration calorimetry. Appl. Magn. Reson. 2020, 51, 877.

2019

Bonnet C, Guillet P, Igonet S, Meister A, Marconnet A, Keller S, Jawhari A, Durand G. Hybrid double-chain maltose-based detergents: synthesis and colloidal and biochemical evaluation. J. Org. Chem. 2019, 84, 10606. PMID 31414599

Krainer G, Keller S, Schlierf M. Structural dynamics of membrane-protein folding from single-molecule FRET. Curr. Opin. Struct. Biol. 2019, 58, 124. PMID 31323499

Ehsan M, Du Y, Mortensen JS, Hariharan P, Qu Q, Ghani L, Das M, Grethen A, Byrne B, Skiniotis G, Keller S, Loland CJ, Guan L, Kobilka BK, Chae PS. Self-assembly behavior and application of terphenyl-cored trimaltosides for membrane-protein studies: impact of detergent hydrophobic group geometry on protein stability. Chem. Eur. J. 2019, 25, 11545. PMID 31243822

Theis J, Gupta TK, Klingler J, Wan W, Albert S, Keller S, Engel BD, Schroda M. VIPP1 rods engulf membranes containing phosphatidylinositol phosphates. Sci. Rep. 2019, 9, 8725. PMID 31217458

August A, Schmidt N, Klingler J, Baumkötter F, Lechner M, Klement J, Eggert S, Vargas C, Wild K, Keller S, Kins S. Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways. J. Neurochem. 2019, 151, 626. PMID 31063592

Danielczak B, Meister A, Keller S. Influence of Mg²⁺ and Ca²⁺ on nanodisc formation by diisobutylene/maleic acid (DIBMA) copolymer. Chem. Phys. Lipids 2019, 221, 30. PMID 30876867

Guillet P, Mahler F, Garnier K, Boussambe GNM, Igonet S, Vargas C, Ebel C, Soulié M, Keller S, Jawhari A, Durand G. Hydrogenated diglucose detergents for membrane-protein extraction and stabilization. Langmuir 2019, 35, 4287. PMID 30767533

Rohr M, Ries F, Herkt C, Gotsmann VL, Westrich LD, Gries K, Trösch R, Christmann J, Chaux-Jukic F, Jung M, Zimmer D, Mühlhaus T, Sommer F, Schroda M, Keller S, Möhlmann T, Willmund F. The role of plastidic trigger factor serving protein biogenesis in green algae and land plants. Plant Physiol. 2019, 179, 1093. PMID 30651302

Höfer CT, Di Lella S, Dahmani I, Jungnick N, Bordag N, Bobone S, Huang Q, Keller S, Herrmann A, Chiantia S. Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes. Biochim. Biophys. Acta Biomembr. 2019, 1861, 1123. PMID 30902626

2018

Frotscher E, Krainer G, Schlierf M, Keller S. Dissecting nanosecond dynamics in membrane proteins with dipolar relaxation upon tryptophan photoexcitation. J. Phys. Chem. Lett. 2018, 9, 2241. PMID 29652505

Karim A, Schulz N, Andersson H, Nekoueishahraki B, Carlsson AC, Sarabi D, Valkonen A, Rissanen K, Gräfenstein J, Keller S, Erdélyi M. Carbon's three-center, four-electron tetrel bond, treated experimentally. J. Am. Chem. Soc. 2018, 140, 17571. PMID 30484646

Krainer G, Treff A, Hartmann A, Stone TA, Schenkel M, Keller S, Deber CM, Schlierf M. A minimal helical-hairpin motif provides molecular-level insights into misfolding and pharmacological rescue of CFTR. Commun. Biol. 2018, 1, 154. PMID 30302398

Atkovska K, Klingler J, Oberwinkler J, Keller S, Hub JS. Rationalizing steroid interactions with lipid membranes: conformations, partitioning, and kinetics. ACS Cent. Sci. 2018, 4, 1155. PMID 30276248

Rao BD, Chakraborty H, Keller S, Chattopadhyay A. Aggregation behavior of pHLIP in aqueous solution at low concentrations: a fluorescence study. J. Fluoresc. 2018, 28, 967. PMID 29959578

Bondar AN, Keller S. Lipid membranes and reactions at lipid interfaces: theory, experiments, and applications. J. Membr. Biol. 2018, 251, 295. PMID 29959445

Boussambe GNM, Guillet P, Mahler F, Marconnet A, Vargas C, Cornut D, Soulié M, Ebel C, Le Roy A, Jawhari A, Bonneté F, Keller S, Durand G. Fluorinated diglucose detergents for membrane-protein extraction. Methods 2018, 147, 84. PMID 29857192

Vargas C, Schönbeck C, Heimann I, Keller S. Extracavity effect in cyclodextrin/surfactant complexation. Langmuir 2018, 34, 5781. PMID 29683671

Frotscher E, Krainer G, Hartmann A, Schlierf M, Keller S. Conformational dynamics govern the free-energy landscape of a membrane-interacting protein. ACS Omega 2018, 3, 12026. PMID 31459283

Grethen A, Glueck D, Keller S. Role of Coulombic repulsion in collisional lipid transfer among SMA(2:1)-bounded nanodiscs. J. Membr. Biol. 2018, 251, 443. PMID 29508005

Krainer G, Hartmann A, Anandamurugan A, Gracia P, Keller S, Schlierf M. Ultrafast protein folding in membrane-mimetic environments. J. Mol. Biol. 2018, 430, 554. PMID 29128595

Danielczak B, Keller S. Collisional lipid exchange among DIBMA-encapsulated nanodiscs (DIBMALPs). Eur. Polym. J. 2018, 109, 206.

2017

Oluwole AO, Klingler J, Danielczak B, Babalola JO, Vargas C, Pabst G, Keller S. Formation of lipid-bilayer nanodiscs by diisobutylene/maleic acid (DIBMA) copolymer. Langmuir 2017, 33, 14378. PMID 29160078

Grethen A, Oluwole AO, Danielczak B, Vargas C, Keller S. Thermodynamics of nanodisc formation mediated by styrene/maleic acid (2:1) copolymer. Sci. Rep. 2017, 7, 11517. PMID 28912575

Ries F, Carius Y, Rohr M, Gries K, Keller S, Lancaster CRD, Willmund F. Structural and molecular comparison of bacterial and eukaryotic trigger factors. Sci. Rep. 2017, 7, 10680. PMID 28878399

Krainer G, Gracia P, Frotscher E, Hartmann A, Gröger P, Keller S, Schlierf M. Slow interconversion in a heterogeneous unfolded-state ensemble of outer-membrane phospholipase A. Biophys. J. 2017, 113, 1280. PMID 28629619

Cuevas Arenas R, Danielczak B, Martel A, Porcar L, Breyton C, Ebel C, Keller S. Fast collisional lipid transfer among polymer-bounded nanodiscs. Sci. Rep. 2017, 7, 45875. PMID 28378790

Rangl M, Rima L, Klement J, Miyagi A, Keller S, Scheuring S. Real-time visualization of phospholipid degradation by outer membrane phospholipase A using high-speed atomic force microscopy. J. Mol. Biol. 2017, 429, 977. PMID 28283404

Frotscher E, Höring J, Durand G, Vargas C, Keller S. Model-free analysis of critical micellar concentrations for detecting demixing in surfactant mixtures. Anal. Chem. 2017, 89, 3245. PMID 28267311

Oluwole AO, Danielczak B, Meister A, Babalola JO, Vargas C, Keller S. Solubilization of membrane proteins into functional lipid-bilayer nanodiscs using a diisobutylene/maleic acid copolymer. Angew. Chem. Int. Ed. 2017, 56, 1919. PMID 28079955

Mungalpara D, Kelm H, Valkonen A, Keller S, Kubik S. Oxoanion binding to a cyclic pseudopeptide containing 1,4-disubstituted 1,2,3-triazole moieties. Org. Biomol. Chem. 2017, 15, 102. PMID 27805227

2016

Cuevas Arenas R, Klingler J, Vargas C, Keller S. Influence of lipid bilayer properties on nanodisc formation mediated by styrene/maleic acid copolymers. Nanoscale 2016, 8, 15016. PMID 27471007

Keller S, Bondar AN, Broecker J, Ladokhin AS, Sinner EK. Journal of Membrane Biology: Biophysics. J. Membr. Biol. 2016, 249, 5. PMID 27097636

Brautigam CA, Zhao H, Vargas C, Keller S, Schuck P. Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions. Nat. Protoc. 2016, 11, 882. PMID 27055097

Panigrahi R, Arutyunova E, Panwar P, Gimpl K, Keller S, Lemieux MJ. Reversible unfolding of rhomboid intramembrane proteases. Biophys. J. 2016, 110, 1379. PMID 27028647

Gimpl K, Klement J, Keller S. Characterising protein/detergent complexes by triple-detection size-exclusion chromatography. Biol. Proced. Online 2016, 18, 4. PMID 26880869

Textor M, Keller S. Calorimetric quantification of cyclodextrin-mediated detergent extraction for membrane-protein reconstitution. Methods Enzymol. 2016, 567, 129. PMID 26794353

Polidori A, Raynal S, Barret LA, Dahani M, Barrot-Ivolot C, Jungas C, Frotscher E, Keller S, Ebel C, Breyton C, Bonneté F. Sparingly fluorinated maltoside-based surfactants for membrane-protein stabilization. New J. Chem. 2016, 40, 5364.