Eine vollständige Publikationsliste finden Sie auf PubMed.
2024
Rigid Cyclic Fluorinated Detergents: Fine-Tuning the Hydrophilic-Lipophilic Balance Controls Self-Assembling and Biochemical Properties. ACS Appl Mater Interfaces. 2024. PMID: 38885044
Exploring membrane asymmetry and its effects on membrane proteins. Trends Biochem Sci. 2024. PMID: 38355393
Towards a Light-mediated Gene Therapy for the Eye using Caged Ethinylestradiol and the Inducible Cre/lox System. Angew Chem Int Ed Engl. 2024. PMID: 38127455
Dimerization and Crowding in the Binding of Interleukin 8 to Dendritic Glycosaminoglycans as Artificial Proteoglycans. Chemistry. 2024. PMID: 38010268
2023
Angerer N, Piller P, Semeraro EF, Keller S, Pabst G. Interaction of detergent with complex mimics of bacterial membranes. Biophys. Chem. 2023. PMID 36921495
Eggenreich L, Vargas C, Kolar C, Keller S. Lipid exchange among electroneutral Sulfo-DIBMA nanodiscs is independent of ion concentration. Biol. Chem. 2023. PMID 36921292
Lenz J, Larsen AH, Keller S, Luchini A. Effect of cholesterol on the structure and composition of Glyco-DIBMA lipid particles. Langmuir 2023, 39, 3569. PMID 36854196
Baron J, Bauernhofer L, Devenish SRA, Fiedler S, Ilsley A, Riedl S, Zweytick D, Glueck D, Pessentheiner A, Durand G, Keller S. FULL-MDS: fluorescent universal lipid labeling for microfluidic diffusional sizing. Anal. Chem. 2023, 95, 587. PMID 36574263
Soulié M, Deletraz A, Wehbie M, Mahler F, Bouchemal I, Le Roy A, Petit-Härtlein I, Keller S, Meister A, Pebay-Peyroula E, Breyton C, Ebel C, Durand G. Zwitterionic fluorinated detergents: from design to membrane protein applications. Biochimie 2023, 205, 40. PMID 36375632
Jeblick T, Leisen T, Steidele CE, Albert I, Müller J, Kaiser S, Mahler F, Sommer F, Keller S, Hückelhoven R, Hahn M, Scheuring D. Botrytis hypersensitive response inducing protein 1 triggers noncanonical PTI to induce plant cell death. Plant Physiol. 2023, 191, 125. PMID 36222581
2022
Janson K, Kyrilis FL, Tüting C, Alfes M, Das M, Träger TK, Schmidt C, Hamdi F, Vargas C, Keller S, Meister A, Kastritis PL. Cryo-electron microscopy snapshots of eukaryotic membrane proteins in native lipid-bilayer nanodiscs. Biomacromolecules 2022, 23, 5084. PMID 36399657
Lee HS, Das M, Mahler F, Ahmed W, Wang H, Mortensen JS, Hariharan P, Ghani L, Byrne B, Guan L, Loland CJ, Keller S, Chae PS. 3,4-Bis(hydroxymethyl)hexane-1,6-diol-based maltosides (HDMs) for membrane-protein study: importance of detergent rigidity–flexibility balance in protein stability. Chem. Asian J. 2022, 17, e202200941. PMID 36253323
Glueck D, Grethen A, Das M, Mmeka OP, Pérez Patallo E, Meister A, Rajender R, Kins S, Räschle M, Victor J, Chu C, Etzkorn M, Köck Z, Bernhard F, Babalola JO, Vargas C, Keller S. Electroneutral polymer nanodiscs enable interference-free probing of membrane proteins in a lipid-bilayer environment. Small 2022, 18, 2202492. PMID 36228092
Piller P, Wolinski H, Cordfunke RA, Drijfhout JW, Keller S, Lohner K, Malanovic N. Membrane activity of LL-37 derived antimicrobial peptides against Enterococcus hirae: superiority of SAAP-148 over OP-145. Biomolecules 2022, 12, 523. PMID 35454112
Danielczak B, Rasche M, Lenz J, Pérez Patallo E, Weyrauch S, Mahler F, Agbadaola MT, Meister A, Babalola JO, Vargas C, Kolar C, Keller S. A bioinspired glycopolymer for capturing membrane proteins in native-like lipid-bilayer nanodiscs. Nanoscale 2022, 5, 1855. PMID 35040850
2021
Schumann R, Bischoff E, Klaus S, Möhring S, Flock J, Keller S, Remans K, Ganter M, Deponte M. Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum. Redox Biol. 2021, 48, 102177. PMID 34773836
Mahler F, Meister A, Vargas C, Durand G, Keller S. Self-assembly of protein-containing lipid-bilayer nanodiscs from small-molecule amphiphiles. Small 2021, 17, 2103603. PMID 34674382
Grousson E, Mahler F, Keller S, Contino-Pépin C, Durand G. Hybrid fluorocarbon–hydrocarbon surfactants: synthesis and colloidal characterization. J. Org. Chem. 2021, 86, 14672. PMID 34609857
Tomazic N, Overkamp KE, Wegner H, Gu B, Mahler F, Aras M, Keller S, Pierik AJ, Hofmann E, Frankenberg-Dinkel N. Exchange of a single amino acid residue in the cryptophyte phycobiliprotein lyase GtCPES expands its substrate specificity. Biochim. Biophys. Acta Bioenerg. 2021, 1862, 148493. PMID 34537203
Janson K, Zierath J, Kyrilis FL, Semchonok DA, Hamdi F, Skalidis I, Kopf AH, Das M, Kolar C, Rasche M, Vargas C, Keller S, Kastritis PL, Meister A. Solubilization of artificial mitochondrial membranes by amphiphilic copolymers of different charge. Biochim. Biophys. Acta Biomembr. 2021, 1863, 183725. PMID 34384757
Hoffmann M, Haselberger D, Hofmann T, Müller L, Janson K, Meister A, Das M, Vargas C, Keller S, Kastritis PL, Schmidt C, Hinderberger D. Nanoscale model system for the human myelin sheath. Biomacromolecules 2021, 22, 3901. PMID 34324309
Hoffmann M, Eisermann J, Schöffmann FA, Das M, Vargas C, Keller S, Hinderberger D. Influence of different polymer belts on lipid properties in nanodiscs characterized by CW EPR spectroscopy. Biochim. Biophys. Acta Biomembr. 2021, 1863, 183681. PMID 34186033
Velazquez-Campoy A, Claro B, Abian O, Höring J, Bourlon L, Claveria-Gimeno R, Ennifar E, England P, Chaires JB, Wu D, Piszczek G, Brautigam C, Tso SC, Zhao H, Schuck P, Keller S, Bastos M. A multi-laboratory benchmark study of isothermal titration calorimetry (ITC) using Ca2+ and Mg2+ binding to EDTA. Eur. Biophys. J. 2021, 50, 4291. PMID 33864101
Wehbie M, Onyia KK, Mahler F, Le Roy A, Deletraz A, Bouchemal I, Vargas C, Babalola JO, Breyton C, Ebel C, Keller S, Durand G. Maltose-based fluorinated surfactants for membrane-protein extraction and stabilization. Langmuir 2021, 37, 2111. PMID 33539092
Eisermann J, Hoffmann M, Schöffmann FA, Das M, Vargas C, Keller S, Hinderberger D. Molecular-level interactions of nanodisc-forming copolymers dissected by EPR spectroscopy. Macromol. Chem. Phys. 2021, 222, 2100051.
2020
Das M, Mahler F, Hariharan P, Wang H, Du Y, Mortensen JS, Patallo EP, Ghani L, Glück D, Lee HJ, Byrne B, Loland CJ, Guan L, Kobilka BK, Keller S, Chae PS. Diastereomeric cyclopentane-based maltosides (CPMs) as tools for membrane protein study. J. Am. Chem. Soc. 2020, 142, 21382. PMID 33315387
Danielczak B, Keller S. Lipid exchange among polymer-encapsulated nanodiscs by time-resolved Förster resonance energy transfer. Methods 2020, 180, 27. PMID 32371238
Adão R, Cruz PF, Vaz DC, Fonseca F, Pedersen JN, Ferreira-da-Silva F, Brito RMM, Ramos CHI, Otzen D, Keller S, Bastos M. DIBMA nanodiscs keep α-synuclein folded. Biochim. Biophys. Acta Biomembr. 2020, 1862, 183314. PMID 32304757
Tso SC, Mahler F, Höring J, Keller S, Brautigam CA. Fast and robust quantification of detergent micellization thermodynamics from isothermal titration calorimetry. Anal. Chem. 2020, 92, 1154. PMID 31829010
Bonnet C, Guillet P, Mahler F, Igonet S, Keller S, Jawhari A, Durand G. Detergent-like polymerizable monomers: synthesis, physicochemical, and biochemical characterization. Eur. J. Org. Chem. 2020, 33, 5340.
Nickolaus C, Vargas C, Reichenwallner J, Chakour M, Selmke B, Chakraborty R, Varadarajan R, Keller S, Trommer WE. The molten globule state of maltose-binding protein: structural and thermodynamic characterization by EPR spectroscopy and isothermal titration calorimetry. Appl. Magn. Reson. 2020, 51, 877.
2019
Bonnet C, Guillet P, Igonet S, Meister A, Marconnet A, Keller S, Jawhari A, Durand G. Hybrid double-chain maltose-based detergents: synthesis and colloidal and biochemical evaluation. J. Org. Chem. 2019, 84, 10606. PMID 31414599
Krainer G, Keller S, Schlierf M. Structural dynamics of membrane-protein folding from single-molecule FRET. Curr. Opin. Struct. Biol. 2019, 58, 124. PMID 31323499
Ehsan M, Du Y, Mortensen JS, Hariharan P, Qu Q, Ghani L, Das M, Grethen A, Byrne B, Skiniotis G, Keller S, Loland CJ, Guan L, Kobilka BK, Chae PS. Self-assembly behavior and application of terphenyl-cored trimaltosides for membrane-protein studies: impact of detergent hydrophobic group geometry on protein stability. Chem. Eur. J. 2019, 25, 11545. PMID 31243822
Theis J, Gupta TK, Klingler J, Wan W, Albert S, Keller S, Engel BD, Schroda M. VIPP1 rods engulf membranes containing phosphatidylinositol phosphates. Sci. Rep. 2019, 9, 8725. PMID 31217458
August A, Schmidt N, Klingler J, Baumkötter F, Lechner M, Klement J, Eggert S, Vargas C, Wild K, Keller S, Kins S. Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways. J. Neurochem. 2019, 151, 626. PMID 31063592
Danielczak B, Meister A, Keller S. Influence of Mg2+ and Ca2+ on nanodisc formation by diisobutylene/maleic acid (DIBMA) copolymer. Chem. Phys. Lipids 2019, 221, 30. PMID 30876867
Guillet P, Mahler F, Garnier K, Boussambe GNM, Igonet S, Vargas C, Ebel C, Soulié M, Keller S, Jawhari A, Durand G. Hydrogenated diglucose detergents for membrane-protein extraction and stabilization. Langmuir 2019, 35, 4287. PMID 30767533
Rohr M, Ries F, Herkt C, Gotsmann VL, Westrich LD, Gries K, Trösch R, Christmann J, Chaux-Jukic F, Jung M, Zimmer D, Mühlhaus T, Sommer F, Schroda M, Keller S, Möhlmann T, Willmund F. The role of plastidic trigger factor serving protein biogenesis in green algae and land plants. Plant Physiol. 2019, 179, 1093. PMID 30651302
Höfer CT, Di Lella S, Dahmani I, Jungnick N, Bordag N, Bobone S, Huang Q, Keller S, Herrmann A, Chiantia S. Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes. Biochim. Biophys. Acta Biomembr. 2019, 1861, 1123. PMID 30902626
2018
Frotscher E, Krainer G, Schlierf M, Keller S. Dissecting nanosecond dynamics in membrane proteins with dipolar relaxation upon tryptophan photoexcitation. J. Phys. Chem. Lett. 2018, 9, 2241. PMID 29652505
Karim A, Schulz N, Andersson H, Nekoueishahraki B, Carlsson AC, Sarabi D, Valkonen A, Rissanen K, Gräfenstein J, Keller S, Erdélyi M. Carbon's three-center, four-electron tetrel bond, treated experimentally. J. Am. Chem. Soc. 2018, 140, 17571. PMID 30484646
Krainer G, Treff A, Hartmann A, Stone TA, Schenkel M, Keller S, Deber CM, Schlierf M. A minimal helical-hairpin motif provides molecular-level insights into misfolding and pharmacological rescue of CFTR. Commun. Biol. 2018, 1, 154. PMID 30302398
Atkovska K, Klingler J, Oberwinkler J, Keller S, Hub JS. Rationalizing steroid interactions with lipid membranes: conformations, partitioning, and kinetics. ACS Cent. Sci. 2018, 4, 1155. PMID 30276248
Rao BD, Chakraborty H, Keller S, Chattopadhyay A. Aggregation behavior of pHLIP in aqueous solution at low concentrations: a fluorescence study. J. Fluoresc. 2018, 28, 967. PMID 29959578
Bondar AN, Keller S. Lipid membranes and reactions at lipid interfaces: theory, experiments, and applications. J. Membr. Biol. 2018, 251, 295. PMID 29959445
Boussambe GNM, Guillet P, Mahler F, Marconnet A, Vargas C, Cornut D, Soulié M, Ebel C, Le Roy A, Jawhari A, Bonneté F, Keller S, Durand G. Fluorinated diglucose detergents for membrane-protein extraction. Methods 2018, 147, 84. PMID 29857192
Vargas C, Schönbeck C, Heimann I, Keller S. Extracavity effect in cyclodextrin/surfactant complexation. Langmuir 2018, 34, 5781. PMID 29683671
Frotscher E, Krainer G, Hartmann A, Schlierf M, Keller S. Conformational dynamics govern the free-energy landscape of a membrane-interacting protein. ACS Omega 2018, 3, 12026. PMID 31459283
Grethen A, Glueck D, Keller S. Role of Coulombic repulsion in collisional lipid transfer among SMA(2:1)-bounded nanodiscs. J. Membr. Biol. 2018, 251, 443. PMID 29508005
Krainer G, Hartmann A, Anandamurugan A, Gracia P, Keller S, Schlierf M. Ultrafast protein folding in membrane-mimetic environments. J. Mol. Biol. 2018, 430, 554. PMID 29128595
Danielczak B, Keller S. Collisional lipid exchange among DIBMA-encapsulated nanodiscs (DIBMALPs). Eur. Polym. J. 2018, 109, 206.
2017
Oluwole AO, Klingler J, Danielczak B, Babalola JO, Vargas C, Pabst G, Keller S. Formation of lipid-bilayer nanodiscs by diisobutylene/maleic acid (DIBMA) copolymer. Langmuir 2017, 33, 14378. PMID 29160078
Grethen A, Oluwole AO, Danielczak B, Vargas C, Keller S. Thermodynamics of nanodisc formation mediated by styrene/maleic acid (2:1) copolymer. Sci. Rep. 2017, 7, 11517. PMID 28912575
Ries F, Carius Y, Rohr M, Gries K, Keller S, Lancaster CRD, Willmund F. Structural and molecular comparison of bacterial and eukaryotic trigger factors. Sci. Rep. 2017, 7, 10680. PMID 28878399
Krainer G, Gracia P, Frotscher E, Hartmann A, Gröger P, Keller S, Schlierf M. Slow interconversion in a heterogeneous unfolded-state ensemble of outer-membrane phospholipase A. Biophys. J. 2017, 113, 1280. PMID 28629619
Cuevas Arenas R, Danielczak B, Martel A, Porcar L, Breyton C, Ebel C, Keller S. Fast collisional lipid transfer among polymer-bounded nanodiscs. Sci. Rep. 2017, 7, 45875. PMID 28378790
Rangl M, Rima L, Klement J, Miyagi A, Keller S, Scheuring S. Real-time visualization of phospholipid degradation by outer membrane phospholipase A using high-speed atomic force microscopy. J. Mol. Biol. 2017, 429, 977. PMID 28283404
Frotscher E, Höring J, Durand G, Vargas C, Keller S. Model-free analysis of critical micellar concentrations for detecting demixing in surfactant mixtures. Anal. Chem. 2017, 89, 3245. PMID 28267311
Oluwole AO, Danielczak B, Meister A, Babalola JO, Vargas C, Keller S. Solubilization of membrane proteins into functional lipid-bilayer nanodiscs using a diisobutylene/maleic acid copolymer. Angew. Chem. Int. Ed. 2017, 56, 1919. PMID 28079955
Mungalpara D, Kelm H, Valkonen A, Keller S, Kubik S. Oxoanion binding to a cyclic pseudopeptide containing 1,4-disubstituted 1,2,3-triazole moieties. Org. Biomol. Chem. 2017, 15, 102. PMID 27805227
2016
Cuevas Arenas R, Klingler J, Vargas C, Keller S. Influence of lipid bilayer properties on nanodisc formation mediated by styrene/maleic acid copolymers. Nanoscale 2016, 8, 15016. PMID 27471007
Keller S, Bondar AN, Broecker J, Ladokhin AS, Sinner EK. Journal of Membrane Biology: Biophysics. J. Membr. Biol. 2016, 249, 5. PMID 27097636
Brautigam CA, Zhao H, Vargas C, Keller S, Schuck P. Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions. Nat. Protoc. 2016, 11, 882. PMID 27055097
Panigrahi R, Arutyunova E, Panwar P, Gimpl K, Keller S, Lemieux MJ. Reversible unfolding of rhomboid intramembrane proteases. Biophys. J. 2016, 110, 1379. PMID 27028647
Gimpl K, Klement J, Keller S. Characterising protein/detergent complexes by triple-detection size-exclusion chromatography. Biol. Proced. Online 2016, 18, 4. PMID 26880869
Textor M, Keller S. Calorimetric quantification of cyclodextrin-mediated detergent extraction for membrane-protein reconstitution. Methods Enzymol. 2016, 567, 129. PMID 26794353
Polidori A, Raynal S, Barret LA, Dahani M, Barrot-Ivolot C, Jungas C, Frotscher E, Keller S, Ebel C, Breyton C, Bonneté F. Sparingly fluorinated maltoside-based surfactants for membrane-protein stabilization. New J. Chem. 2016, 40, 5364.